Hemoperfusion
Hemoperfusion: Blood purification through adsorption/binding of harmful substances
Modern extracorporeal blood purification methods, such as those used in VitaSangius therapy (like hemoperfusion), have been proven to improve metabolism, the immune system, and organ functions. Organ functions, and thus improve quality of life. They are an effective tool on the path to regeneration and recovery.
Blood purification procedures have a long tradition. So-called “detoxifications” are well-known therapies that have proven effective. The disadvantage is that the elimination of harmful substances must be carried out by the liver and kidneys, which leads to a temporary strain on these organs.
Die extrakorporale Blutreinigung bietet den Vorteil der Blutreinigung, die Leber und Nieren entlastet. Ausleitungsverfahren und extrakorporale Blutreinigungsverfahren können kombiniert werden und so gemeinsam den „Reinigungsprozess“ optimieren.
The development of modern hemoperfusion therapies began in the 1980s. There is extensive data and clinical experience supporting their effectiveness. Whole blood procedures (blood-sparing), volume-neutral methods, and higher flow rates enable a safe and effective process. The average treatment duration is 4 hours. During this time, depending on the flow rate and the patient’s weight, 72-120 liters of blood can be purified (approximately 16-27 times the total blood volume). ).
Je nach Diagnose und Indikation: 2-4 Behandlungen.
Keine relevante Entfernung von Immunglobulinen und Lipiden.
Hemoperfusion is an extracorporeal blood purification procedure that uses highly biocompatible plastics, which, due to their physicochemical properties, are capable of binding various substances. This process is called adsorption or hemoadsorption. We use adsorbers that have a specific or a nonspecific, broad adsorption spectrum.
The adsorber with the broader adsorption spectrum operates in a concentration-dependent manner. This means that at high concentrations, larger quantities of cytokines, chemokines, toxins, and breakdown products, etc., can be removed very quickly. Higher flow rates support the effectiveness of this treatment.
As the concentration decreases, the elimination rate also decreases. This concentration-dependent autoregulation is intended to prevent the complete removal of physiological substances.
Adsorption spectrum:
In contrast to plasmapheresis, hemoperfusion does not separate blood components and plasma using a plasma separator. Therefore, this treatment is also referred to as a whole blood procedure and is volume-neutral. It differentiates between specific adsorption, non-specific adsorption, and cytapheresis.
The development of whole blood adsorbers began in the 1980s. They are now used worldwide in clinics, including in intensive care units, to therapeutically manage severe disease courses such as sepsis. This relatively new blood purification method is simple, low-risk, and effective.
Benefits of Hemoperfusion:
• Whole blood procedure
• Volume-neutral
• Size-selective removal of hydrophobic substances
• Broad, effective adsorption spectrum with concentration-dependent elimination (hemoadsorption)
• Specific adsorption of LPS (lipopolysaccharide)
• Cytapheresis: adsorption of activated, excessive blood cells that can cause colonic inflammations, such as ulcerative colitis
Additionally, hemoperfusion can be combined with hyperthermia (heat) and hyperoxygenation (increased oxygen supply).
(controlled blood hyperthermia)
Blood hyperthermia focuses on the precise control of blood temperature. The gentle warming of the blood ensures a continuous heating from the inside out and is generally well tolerated. Many patients often tolerate this form of hyperthermia better than extreme whole-body hyperthermia.
A heat exchanger is integrated into the extracorporeal system and connected to a heating device. This heating device can be individually adjusted to precisely and controllably regulate the blood temperature. The vessels dilate, microcirculation is stimulated, and thus better tissue perfusion is achieved. Hyperthermia has a positive impact on the immune system.
The additional supply of oxygen through an oxygenation unit increases the physically dissolved oxygen content in the blood.
This facilitates the delivery of oxygen to the tissues and increases the oxygen supply for the cells. The effects include, among others, vasodilation and anti-inflammatory properties.
The flow properties (viscosity) of the blood and microcirculation improve. Hyperoxygenation, like hyperthermia, has a positive effect on the immune system.
The additional supply of oxygen through an oxygenation unit increases the physically dissolved oxygen content in the blood.
This facilitates the delivery of oxygen to the tissues and increases the oxygen supply for the cells. The effects include, among others, vasodilation and anti-inflammatory properties.
The flow properties (viscosity) of the blood and microcirculation improve. Hyperoxygenation, like hyperthermia, has a positive effect on the immune system.
Hemoperfusion indications:
- Cancer
- Support for standard procedures that are accompanied by side effects
- Removal of toxic substances
- Reduction of hyperinflammation
- Balancing of the immune system (immunomodulation)
- Improvement of organ function
- Liver dysfunction
- Chronic fatigue Syndrom
- Chronic inflammatory diseases such as Lyme disease, rheumatism, Crohn’s disease, ulcerative colitis, and others.
Additionally, hemoperfusion can be combined with controlled blood hyperthermia (heat therapy) and hyperoxygenation (increased oxygen supply).
VitaSangius offers more than just extracorporeal blood purification. With targeted diagnostics and the resulting indication, you will receive your individualized treatment as part of our therapy offerings.
VitaSangius offers more than just extracorporeal blood purification. With targeted diagnostics and the resulting indication, you will receive your personalized treatment as part of our therapy offerings.
Extracorporeal blood purification methods are technically more complex but minimally invasive and, with today’s advancements, are easy to use, low-risk, and effective. They are gentle on liver and kidney function.
Detoxification procedures and extracorporeal blood purification methods can, when indicated, be combined with each other.
What Our Patients Say
FAQ
As we perform various blood purification methods, an accurate diagnosis/diagnostic is essential to determine the appropriate procedure for you.
Hemoperfusion is an extracorporeal, minimally invasive procedure. These therapies are effective but can also be tiring, so it is recommended to have an accompanying person present.
Since hemoperfusion does not require anesthesia, you do not need to fast. You can eat as usual and should ensure adequate hydration.
As a minimally invasive procedure, hemoperfusion requires puncture with cannulas. This puncture may cause a minimal, short-term pain, which can be minimized with local anesthesia and/or intravenous pain management. The hemoperfusion procedures are generally pain-free.
On the day of the hemoperfusion and for the next 3 days, physical exertion should be minimized and adequate hydration should be ensured.
The treatment duration is usually 4 hours.
The day after hemoperfusion, we perform a wound inspection of the puncture site of the Sheldon catheter. Normally, no further treatments regarding the minimally invasive procedure are necessary thereafter.
Depending on the diagnostics, indications, and procedure, between 1 and 5 hemoperfusion sessions may be required.
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